Take supplements with food or empty stomach?

It depends on the supplement. Fat-soluble vitamins (A, D, E, K) are better absorbed with a meal that contains some fat. Some minerals (e.g. iron, zinc) can cause nausea on an empty stomach, so taking them with food may improve tolerance; however, certain foods (e.g. calcium, tannins in tea) can reduce iron absorption, so timing may need to be considered. Magnesium with dinner may support relaxation and sleep for some people. B vitamins are often taken with food to reduce stomach upset. Probiotics may be taken with or without food depending on the product. Read the label and, when in doubt, take with a small meal unless your provider advises otherwise. This is educational only.